Introduction to Psoriasis

Posted by e-Medical PPT
Genetics and Pathogenesis
Psoriasis and the Immune System
 The major histocompatibility complex (MHC)
  Short arm of chromosome 6
 Histocompatibility Antigens (HLA)
  HLA-Cw6
  HLA-B13, -B17, -B37, -Bw16
 T-lymphocyte-mediated mechanism

Psoriasis as a Systemic Disease
Koebner Phenomenon
Elevated ESR
Increased uric acid levels → gout
Mild anemia
Elevated α2-macroglobulin
Elevated IgA levels
Increased quantities of Immune Complexes
Psoriatic arthropathy
Aggravation of psoriasis by systemic factors
Medication
Focal infections
Stress
Life-threatening forms of psoriasis

Clinical Variants of Psoriasis
Characteristic Lesion of Psoriasis
Sharply demarcated erythematous plaque with micaceous silvery white scale
 Histopathology
 Thickening of the epidermis
 Tortuous and dilated blood vessels
 Inflammatory infiltrate primarily of lymphocytes

Three Cardinal Signs of Psoriatic Lesions   
Plaque elevation
Erythema
Scale

Chronic Plaque Psoriasis
Most Common Variant
Plaques may be as large as 20 cm
Symmetrical disease
Sites of Predilection
 Elbows,Knees,Presacrum,Scalp,Hands and Feet..

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