Q-Fever(Coxiella burnetii)

Posted by e-Medical PPT
Q fever is a zoonotic disease caused by Coxiella burnetii
Obligate intracellular, gram negative bacterium
Distributed globally
Found in many species of animals

Transmission
Most common route is inhalation of aerosols
Contaminated dust, manure, birthing products
Tick bites (rare)
Human to human also very rare

Symptoms
Acute Q fever
Self-limiting, flu-like disease
Fever, nausea, headaches, vomiting, chest/abdominal pain
Pneumonia and granulomatous hepatitis

Chronic Q fever (> 6 months)
Endocarditis & meningoencephalitis
Pre-existing disease

Diagnosis
Hard to diagnose because:
Asymptomatic in most cases
Looks like other disease (Flu or cold)
Serology continues to be best method
PCR, ELISA and other methods
Bio safety level 3 (BSL-3) facility
Very infectious (one organism causes infection)
Listed by the CDC as a potential bioterrorism agent.
Isolated in cell cultures or embryonated eggs

Control/Prevention
Pasteurization and sterilization of milk and other dairy products
Disinfect utensils, machines used in farm areas for birthing
Regular testing of animals and those who work closely with them
Protective Personal Equipment

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