Vasculitis Review

Posted by e-Medical PPT
Vasculitis: Inflammation of blood vessels causing vessel and tissue damage
Classification is according to the Chapel Hill Consensus Conference of 1994
Large-vessel vasculitides
Medium-vessel vasculitides
Small-vessel vasculitides (many)
Non-ANCA-associated (many)

Large Vessel Vasculitides
Giant cell arteritis (formerly called temporal arteritis)
Takayasu’s arteritis
Distinguished only by age of pt > or < 50 yo
Both involve the aorta and its primary branches

Medium Vessel Vasculitides
Polyarteritis nodosa (PAN)
Buerger’s = Thromboangiitis obliterans
Kawasaki’s disease = Mucocutaneous LN syndrome

Small Vessel Vasculitides
Wegener’s granulomatosis (WG)
Churg-Strauss syndrome (CSS)
Microscopic polyangiitis (MPA) – no granulomas
Drug-induced ANCA vasculitis

Infectious (Hep B, Hep C, HIV, Parvo, CMV, EBV)
CVD-related (RA, SLE, Bechet’s, Sjogren’s)
Drug-related (cutaneous leukocytoclastic angiitis)
Henoch-Schonlein Purpura (HSP) – IgA deposits
Goodpasture’s disease
Urticarial vasculitis
Paraneoplastic vasculitis

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