Pancreatic Pseudocyst

Posted by e-Medical PPT
A fluid collection contained within a well-defined capsule of fibrous or granulation tissue or a combination of both
Does not possess an epithelial lining
Persists more than 4 weeks
May develop in the setting of acute or chronic pancreatitis
Most common cystic lesions of the pancreas, accounting for 75-80% of such masses
Location
Lesser peritoneal sac in proximity to the pancreas
Large pseudocysts can extend into the paracolic gutters, pelvis, mediastinum, neck or scrotum
May be loculated
Thick fibrous capsule – not a true epithelial lining
Pseudocyst fluid
Similar electrolyte concentrations to plasma
High concentration of amylase, lipase, and enterokinases such as trypsin

Pathophysiology
Pancreatic ductal disruption secondary to
Acute pancreatitis – Necrosis
Chronic pancreatitis – Elevated pancreatic duct pressures from strictures or ductal calculi
Trauma
Ductal obstruction and pancreatic neoplasms.

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