SIRS is a serious condition related to systemic inflammation, organ dysfunction, and organ failure.
Criteria for SIRS were established as part of the American College of Chest Physicians/Society of Critical Care Medicine Consensus Conference.The conference concluded that the manifestations of SIRS include, but are not limited to:
    * Body temperature less than 36°C or greater than 38°C
    * Heart rate greater than 100 beats per minute
    * Tachypnea with greater than 20 breaths per minute; or, an arterial partial pressure of carbon dioxide less than 32 mmHg
    * White blood cell count less than 4000 cells/mm³ (4 x 109 cells/L) or greater than 12,000 cells/mm³ (12 x 109 cells/L); or the presence of greater than 10% immature neutrophils (band forms)

SIRS can be diagnosed when two or more of these criteria are present.
Fever and leukocytosis are features of the acute-phase reaction, while tachycardia is often the initial sign of hemodynamic compromise. Tachypnea may be related to the increased metabolic stress due to infection and inflammation.SIRS is frequently complicated by failure of one or more organs or organ systems.The complications of SIRS include:
    * Acute lung injury
    * Acute kidney injury
    * Shock
    * Multiple organ dysfunction syndrome


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