Rhabdomyolysis

Posted by e-Medical PPT
Rhabdomyolysis is a condition in which injury to skeletal muscle tissue causes it to quickly break down. This results in the release of myoglobin and other breakdown products into the bloodstream. Acute kidney failure (acute renal failure) may result from such a situation.
Rhabdomyolysis may be caused by any one of a variety of means. Essentially, any situation causing muscle tissue destruction has the potential to be a rhabdomyolysis cause. These are considered to be either physical or non-physical causes. Rhabdomyolysis brought on by physical causes tends to be restricted to one region of the patient's body, whereas non-physical rhabdomyolysis typically harms all of the body's muscles at once.

Physical rhabdomyolysis causes
Traumatic muscle compression - car accident, crush syndrome,physical abuse, etc.
Blood supply to muscle obstruction - arterial thrombosis, artery clamping, embolism, reduced blood supply (in shock or sepsis), etc.
Excessive activity in muscles - Alcohol withdrawal (delirium tremens), extreme physical exercise,persistent seizures (status epilepticus, SE), tetanus, etc.
Electrical shock - high voltage electric shock

Non-physical rhabdomyolysis causes
Autimmune muscle damage - dermatomyositis, polymyositis, etc.
Disturbances of electrolytes or metabolism - hypernatremia and hyponatremia, hypocalcemia , hypokalemia, hypophosphatemia, hypothyroidism, increased plasma osmolality, ketoacidosis, etc.
Infections - Coxsackie virus, herpes virus, Legionella pneumophila, malaria (Plasmodium falciparum), Salmonella, tularemia (Francisella tularensis), etc.
Muscle energy supply disorders - carnitine palmitoyltransferase I deficiency or carnitine palmitoyltransferase I deficiencyprimary carnitine deficiency (CPT type I or II), McArdle's disease, mitochondrial respiratory chain defects, phosphofructokinase deficiency, primary carnitine deficiency, VLCAD deficiency, etc.


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