Paget's disease of the bone is a chronic disorder that typically results in enlarged and deformed bones.The pathogenesis of Paget's disease is described in 3 stages, which are:Osteoclastic activity,Mixed osteoclastic-osteoblastic activity
and Exhaustive (burnt out) stage.
Paget's disease is rarely diagnosed in people less than 40 years of age. Men are more commonly affected than women. Prevalence of Paget's disease ranges from 1.5 to 8.0 percent, depending on age and country of residence. Prevalence of familial Paget's disease ranges from 10 to 40 percent in different parts of the world.Because early diagnosis and treatment is important, after age 40, siblings and children of someone with Paget's disease may wish to have an alkaline phosphatase blood test every two or three years. If the alkaline phosphatase level is above normal, other tests such as a bone-specific alkaline phosphatase test, bone scan, or X-ray can be performed.
Many patients do not know they have Paget's disease because they have a mild case with no symptoms.Symptoms can include:
    * Bone pain is the most common symptom. It can occur in any bone affected by Paget's disease. It often localizes to areas adjacent to the joints.
    * Headaches and hearing loss may occur when Paget's disease affects the skull.
    * Pressure on nerves may occur when Paget's disease affects the skull or spine.
    * Paralysis may be due to vascular steal syndrome of the vertebrae.
    * Increased head size, bowing of limb, or curvature of spine may occur in advanced cases.
    * Hip pain may occur when Paget's disease affects the pelvis or thighbone.
    * Chalkstick fractures can occur.
    * Mosaic bone pattern is symptomatic.
    * Hypercementosis in teeth may occur.


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