Type 1 Diabetes

Posted by e-Medical PPT
Diabetes mellitus type 1 is a form of diabetes mellitus that results from autoimmune destruction of insulin-producing beta cells of the pancreas.The subsequent lack of insulin leads to increased blood and urine glucose.Type 1 is treated with insulin replacement therapy—either via subcutaneous injection or insulin pump, along with attention to dietary management.Pancreas and islet transplants have been used to treat type 1 diabetes; however, islet transplants are currently still at the experimental trial stage.
Most people who develop type 1 are otherwise healthy.The classical symptoms of type 1 diabetes include: polyuria,polydipsia,polyphagia,tiredness and weight loss.Diabetes mellitus is characterized by recurrent or persistent hyperglycemia, and is diagnosed by demonstrating any one of the following:
    * Fasting plasma glucose level at or above 7.0 mmol/L (126 mg/dL).
    * Plasma glucose at or above 11.1 mmol/L (200 mg/dL) two hours after a 75 g oral glucose load as in a glucose tolerance test.
    * Symptoms of hyperglycemia and casual plasma glucose at or above 11.1 mmol/L (200 mg/dL).
    * Glycated hemoglobin  at or above 6.5.
Type 1 can be distinguished from type 2 diabetes via a C-peptide assay, which measures endogenous insulin production.


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