Pharmacology of Antipsychotics

Posted by e-Medical PPT
Dopamine Hypothesis
Drugs that increase dopamine will enhance or produce positive psychotic symptoms
E.G. Cocaine, amphetamine
All known antipsychotics drugs capable of treating positive psychotic symptoms block the dopamine receptors

Dopamine Pathways
Mesolimbic
Projects from brainstem to limbic areas.
Overactivity produces delusions and hallucinations.

Nigrostriatal
Projects from the substania nigra to the basal ganglia
A part of the extrapyramidal system
Thus side effects are called “extrapyramidal”
Controls movements
Types of movement disorders caused by this pathway include:
Akathisia,Dystonia,Tremor, rigidity, bradykinesia
Drug-induced Parkinsonism

Mesocortical
May be associated with both positive and negative symptoms
Blockade may help reduce negative symptoms of schizophrenia
May be involved in the cognitive side effects of antipsychotics “mind dulling”

Tuberoinfundibular - Blockade produces galactorrhea


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