Malignant Mesothelioma

Posted by e-Medical PPT
Mesothelioma is an insidious neoplasm arising from the mesothelial surfaces of the pleural and peritoneal cavities, the tunica vaginalis, or the pericardium.
Causes
The vast majority of mesothelioma cases are attributed to asbestos exposure. 
Less common causes of mesothelioma include:
Radiation therapy
Erionite fibers (genetic susceptibility)
Collapsotherapy (the induction of artificial pneumothorax or pneumoperitoneum for treatment of tuberculosis)
The DNA tumor virus SV40

Industries with High Incidence of Mesothelioma
Construction (carpenters, plumbers, electricians, insulators)
Ship and boat building
Manufacture of cement products
Manufacture of non-metallic mineral products (including asbestos)
Glass products manufacturing
Generation of electricity
Brick and ceramic products manufacturing

No chemotherapy regimen for mesothelioma has proven curative , but several regimes are valuable for palliation. These treatments not only decrease tumor burden but also improve symptoms such as pain, breathlessness and chest wall masses. Untill 5 years ago, comprehensive reviews of chemotherapy and mesothelioma were unable to recommend any particular therapy as a standard of care because of the low RR. Two therapeutic regimens  have since proven to be of value.

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